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phenobarbital will lower the extent or influence of olanzapine/samidorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Strong CYP3A4 inducers lower amounts of olanzapine and samidorphan by~50% and ~seventy five% respectively.phenobarbital decreases amounts of vandetanib by affecting hepatic/intest